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KMID : 1145120210190040639
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Asian Journal of Beauty and Cosmetology
2021 Volume.19 No. 4 p.639 ~ p.649
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Whitening and Moisturizing Effects of Hydrolyzed Swiftlet Nest Extracts
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Kim Yun-Jeong
Kim Young-Sam
Goh Ye-Sol
Lee Hyun-Sang
Cheung Waiting
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Abstract
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Purpose : This research verified the skin whitening and moisturizing effects of hydrolyzed swiftlet nest extracts (HSNE) in vitro using human keratinocytes and melanoma.
Methods : To confirm the antioxidant effect of HSNE, DPPH radical-scavenging activity was measured. To find out the whitening effect of HSNE, the genes related to melanogenesis, mRNA expression of tyrosinase (TYR), tyrosinase related protein (TRP) 1, 2 and microphthalmia associated transcription factor (MITF) were measured. We also measured the melanin contents after treatment of HSNE to confirm the anti-melanogenesis effect. Using reverse transcription polymerase chain reaction (RT-PCR), the genes related to moisturizing such as aquaporin (AQP) 3, hyaluronan synthase (HAS) 1, 2, and 3 were determined. The results of the tests were analyzed with student’s t-test and expressed as mean±standard deviation.
Results : DPPH radical scavenging effects of HSNE increased in a concentration dependent manner. The expression of melanogenesis-related genes were inhibited by the treatment of HSNE in a concentration-dependent manner (MITF, TYR, TRP1, and 2). Melanin contents also decreased with the treatment of HSNE. The expression of moisturizing-related genes (HAS1, 2, 3, and AQP3) increased in a concentration-dependent manner.
Conclusion : It is confirmed that the hydrolyzed swiftlet nest extracts have skin whitening and moisturizing effects and can be used as a functional cosmetic raw material.
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KEYWORD
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Hydrolyzed swiftlet nest extracts, Moisturizing, Whitening, Anti-oxidant, Cosmetic raw material
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